If your bloods tests do not show that you need treatment then depending on the reason for the overdose we may ask the Mental Health Liaison team to come and see you to provide you with support. Treatment of overdose Paracetamol overdose is treated with a vitamin infusion known as Parvolex. This is given to you for at least twenty one hours after an overdose to prevent the damage to your liver. Parvolex provides you with gluthathione which your body uses to break down paracetamol and other medications.
Parvolex does not cause an allergic reaction but can cause itching, rashes and wheeze. If you have had problems with this medication before or develop any of these symptoms during your treatment, please let us know and we will give you other medications to prevent the side effects. In addition, we will give you the medication at a slower rate which means you may have to stay in hospital for a bit longer.
When to seek urgent help? If you develop any of the following symptoms, you must seek medical advice immediately. Abdominal stomach pain, nausea, vomiting sickness. Paracetamol should start to work within an hour and the effect usually lasts several hours. Don't take more than the recommended dose if it isn't relieving your symptoms. Adults can take ibuprofen at the same time if necessary, but this isn't usually recommended for children.
Contact your GP or phone NHS 24 service if your symptoms get worse or last more than 3 days despite taking paracetamol. Be careful not to use other medications that contain paracetamol as an ingredient such as some cold and flu remedies while you're taking paracetamol. Paracetamol can react unpredictably with certain other medications.
This can affect how well either medicine works and might increase the risk of side effects. Check the leaflet that comes with your medicine to see if it can be taken with paracetamol.
Ask a pharmacist or doctor if you're not sure. There are no known problems caused by taking paracetamol with any specific foods or by drinking moderate amounts of alcohol while taking paracetamol. Speak to a pharmacist or doctor if you develop any troublesome side effects that you think could be caused by paracetamol. You can also report suspected side effects using the Yellow Card Scheme. Significant overdose can result in liver failure if not promptly treated with the antidote. Paracetamol is usually taken by mouth and is available in various ways, such as in tablet, caplet, soluble and liquid forms.
They will pass to the stomach and intestine into the body and lead to pain relief and lowering of a high temperature fever. After this, paracetamol is inactivated before being removed from the body. As a result a small amount of a toxic compound n-acetyl-p-benzoquinone imine, or NAPQI is formed in the liver but is quickly detoxified by a substance called glutathione. However in overdose the stores of glutathione can be depleted so that there isn't enough to remove the increased amounts of NAPQI.
Paracetamol is the most common medicine taken in overdose. It can lead to liver failure in a number of days, despite using medication to protect the liver. Liver failure can be fatal. There are many reasons for someone to take an overdose.
This could be to end one's life or to cause serious self-harm. An overdose can also be taken accidentally - for example, toddlers and people with poor eyesight.
In some, the act of taking an overdose is a spur-of-the-moment thing, whilst in others it can be pre-planned. Those who have pre-planned may have stockpiled medication, sorted out their affairs such as writing a will and also written a suicide note.
Some people take higher-than-recommended doses of paracetamol for pain over several days. They may not intend to kill themselves, and occasionally may not even realise they are harming themselves until they begin to feel unwell. Paracetamol is widely available from shops and is present in most homes. The government has made rules to limit how much can be bought in one go, which may help reduce the number of overdoses.
Child paracetamol dosages revised. Painkillers 'risky in pregnancy'. British Journal of Clinical Pharmacology. Scottish Liver Transplant Unit.
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