Merck Manual Professional Version. Hypothyroidism myxedema. Updated May TRH stimulation when basal TSH is within the normal range: is there "sub-biochemical" hypothyroidism?.
Clin Med Res. The dynamic pituitary response to escalating-dose TRH stimulation test in hypothyroid patients treated with liothyronine or levothyroxine replacement therapy. J Clin Endocrinol Metab. Thyrotropin releasing hormone TRH. Updated May 22, Pituitary apoplexy after thyrotropin-releasing hormone stimulation test in a patient with pituitary macroadenoma.
J Chin Med Assoc. J Clin Res Pediatr Endocrinol. TRH-induced secretion of adrenocorticotropin and cortisol in dogs with pituitary-dependent hypercortisolism. Vet Q.
Pituitary response to thyrotropin releasing hormone in children with overweight and obesity. Sci Rep. Your Privacy Rights. To change or withdraw your consent choices for VerywellHealth. At any time, you can update your settings through the "EU Privacy" link at the bottom of any page. These choices will be signaled globally to our partners and will not affect browsing data. We and our partners process data to: Actively scan device characteristics for identification.
I Accept Show Purposes. Table of Contents View All. Table of Contents. Purpose of Test. Risks and Contraindications. Before the Test. What to Bring. During the Test. After the Test. Interpreting Results. Thyroid Function Tests and Normal Ranges. Pros and Cons of Clinical Trials. When to Seek Urgent Care If you experience dizziness, palpitations, vision changes, chest pain, vomiting, severe headaches, or convulsions, get urgent medical attention right away.
Was this page helpful? Thanks for your feedback! A series of women attending a specialized endocrine unit were evaluated. A standardized i. TSH levels were measured both in the basal and the 30 minute blood sample. The normal response to TRH stimulation had been previously determined to be an absolute value lying between 2. Both TSH values were analyzed by cross tabulation. In addition the results were compared to reference values taken from the literature.
Basal TSH values were within the normal range 0. Based on the response to TRH, Combining the data on basal and stimulated TSH levels, latent hypothyroidism was found in the following proportions for different TSH levels: 5. The use of an upper normal range for TSH of 2. Our analysis strategy allows us to delineate the predictive value of basal TSH levels in relation to latent hypothyroidism. A grey area can be identified for values between 3. Peer Review reports. Elevated levels of TSH are the hallmark of decreased thyroid function.
In order to correctly identify these patients it is imperative to have a clear definition of the upper reference range for basal TSH. Patients whose TSH lies in the upper reference range might appear to have minimal thyroid deficiency.
Although this might appear to be an easy task, the definition of the upper reference range for TSH has been matter of controversial debate [ 1 — 5 ]. Reported reference values for the upper range of basal TSH vary between 2. Within the setting of a fertility unit, the exclusion or identification of causes of infertility requires a broad diagnostic approach.
In a recent review by Poppe, Velkeniers, and Glinoer, special emphasis was put on the evaluation of thyroid function [ 25 ]. Referring to thyroid function tests, the authors commented the apparent discrepancy between basal and TRH-stimulated TSH levels used to detect subclinical hypothyroidism Table 1 in [ 25 ]. The aim of this retrospective study was to describe in more detail the relation of basal TSH levels to the TRH-stimulated levels and their validity for the detection of latent hypothyroidism.
Data analysis was also carried out in comparison with criteria reported in the literature. The laboratory methods used have been described elsewhere [ 17 ]. A total of women attending the out-patient unit for Reproductive Endocrinology at the University of Innsbruck were studied mean age 31 years, min. All patients were ambulatory and did not present any severe disease nor were taking any medication that could interfere with thyroid function tests.
Ninety percent of patients were consulting the service due to irregularities of the menstrual cycle, or infertility. Ten percent of cases corresponded to menopausal women. Patients with known thyroid disease were excluded. Informed consent was obtained according to the Declaration of Helsinki. The study was approved by the institutional Ethics Committee. The TRH test was carried out by i. Both a basal and a 30 minute blood sample were obtained. Antibody levels were not determined.
These reference values will be called I-TSH in further comparisons. An absolute TSH increase between 2. The definition of these levels comes from a detailed internal evaluation of both clinical and laboratory data of patients being investigated at the out-patient unit of the Department of Nuclear Medicine, University of Innsbruck in Donaldson 2 3 1.
Personalised recommendations. Cite chapter How to cite? ENW EndNote. High TSH levels can mean your thyroid is not making enough thyroid hormones, a condition called hypothyroidism. Low TSH levels can mean your thyroid is making too much of the hormones, a condition called hyperthyroidism.
If your test results are abnormal, your health care provider will probably order additional tests to determine the cause of your thyroid problem.
These tests may include:. Learn more about laboratory tests, reference ranges, and understanding results. Thyroid changes can happen during pregnancy. These changes are usually not significant, but some women can develop thyroid disease during pregnancy. Hyperthyroidism occurs in about one in every pregnancies, while hypothyroidism occurs in approximately one in every pregnancies.
Hyperthyroidism, and less often, hypothyroidism, may remain after pregnancy. If you develop a thyroid condition during pregnancy, your health care provider will monitor your condition after your baby is born.
If you have a history of thyroid disease, be sure to talk with your health care provider if you are pregnant or are thinking of becoming pregnant. The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.
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